| Total | 120 | 75 | (62%) | 31 | (26%) | 14 | (12%) |
| Casa | 60 | 39 | (65%) | 16 | (27%) | 5 | (8%) |
| Fuera | 60 | 36 | (60%) | 15 | (25%) | 9 | (15%) |
E | 2021-10-16 | Mighty Wanderers |  | 0-0 |  | Moyale Barracks | C | ||
D | 2021-10-03 | Mighty Wanderers | | 1-3 |  | Blue Eagles | C | ||
V | 2021-09-30 | Mighty Wanderers | | 2-0 |  | Ekwendi Hammers | C | ||
V | 2021-09-26 | Big Bullets |  | 0-1 | | Mighty Wanderers | C | ||
V | 2021-09-22 | Tigers FC |  | 0-1 | | Mighty Wanderers | C | ||
V | 2021-09-11 | Silver Strikers |  | 0-1 | | Mighty Wanderers | C | ||
E | 2021-08-21 | Ntopwa FC |  | 0-0 | | Mighty Wanderers | C | ||
V | 2021-08-14 | Mighty Wanderers | | 2-0 |  | Civil Sporting Club | C | ||
E | 2021-07-31 | MAFCO FC |  | 0-0 | | Mighty Wanderers | C | ||
V | 2021-06-19 | Mighty Wanderers | | 3-2 |  | Mzuzu University | C | ||
V | 2021-06-16 | Red Lions |  | 0-2 | | Mighty Wanderers | C | ||
V | 2021-06-05 | Mighty Wanderers | | 1-0 |  | TN Stars FC | C | ||
V | 2021-05-30 | Chitipa United |  | 0-2 | | Mighty Wanderers | C | ||
D | 2021-05-29 | Karonga United |  | 2-0 | | Mighty Wanderers | C | ||
V | 2021-05-22 | Mighty Wanderers | | 2-0 |  | Kamuzu Barracks | C | ||
V | 2021-05-15 | Civil Sporting Club | | 1-2 | | Mighty Wanderers | C | ||
E | 2021-05-08 | Mighty Wanderers | | 1-1 | | Red Lions | C | ||
E | 2021-05-01 | Mighty Wanderers | | 1-1 | | Big Bullets | C | ||
E | 2021-04-18 | Blue Eagles | | 2-2 | | Mighty Wanderers | C | ||
V | 2021-04-14 | Mighty Wanderers | | 4-1 | | Ntopwa FC | C |
