| 2021/12/05 | Portland Timbers |  | 2-0 |  | Real Salt Lake |
| 2 |
|
Hany Mukhtar Nashville SC | 19 G |
| 2 |
|
Ola Kamara DC United | 19 G |
| 4 |
|
Adam Buksa NE Revolution | 17 G |
| 4 |
|
Raúl Ruidíaz Seattle Sounders | 17 G |
| 1 |
|
Djordje Mihailovic CF Montréal | 14 AST: |
| 3 |
|
Maxi Morález New York City FC | 13 AST: |
| 4 |
|
Jack Price Colorado Rapids | 12 AST: |
| 5 |
|
Hany Mukhtar Nashville SC | 10 AST: |
