| h2h | 2021-01-26 | 20:30 | (C) | Hamburger SV | - | J18 | FF | |
| h2h | 2021-01-29 | 18:30 | (F) | Wurzburger Kickers | - | J19 | FF | |
| h2h | 2021-02-08 | 20:30 | (C) | Holstein Kiel | - | J20 | FF | |
| h2h | 2021-02-13 | 13:00 | (F) | Jahn Regensburg | - | J21 | FF | |
| h2h | 2021-02-21 | 13:30 | (C) | Hannover 96 | - | J22 | FF | |
| h2h | 2021-02-28 | 13:30 | (F) | 1. FC Heidenheim 1846 | - | J23 | FF | |
| h2h | 2021-03-07 | 01:00 | (C) | FC Nürnberg | - | J24 | FF | |
| h2h | 2021-03-14 | 01:00 | (F) | SV Sandhausen | - | J25 | FF | |
| h2h | 2021-03-21 | 01:00 | (C) | VfL Bochum | - | J26 | FF | |
| h2h | 2021-04-04 | 01:00 | (F) | Darmstadt 98 | - | J27 | FF | |
| h2h | 2021-04-11 | 01:00 | (C) | Karlsruher SC | - | J28 | FF | |
| h2h | 2021-04-18 | 01:00 | (F) | VfL Osnabrück | - | J29 | FF | |
| h2h | 2021-04-21 | 01:00 | (C) | FC St. Pauli | - | J30 | FF | |
| h2h | 2021-04-25 | 01:00 | (F) | SC Paderborn 07 | - | J31 | FF | |
| h2h | 2021-05-09 | 01:00 | (C) | Eintracht Braunschweig | - | J32 | FF | |
| h2h | 2021-05-16 | 15:30 | (C) | Erzgebirge Aue | - | J33 | FF | |
| h2h | 2021-05-23 | 15:30 | (F) | SpVgg Greuther Fürth | - | J34 | FF |
